UKUSETSHENZISWA KWE-GELATIN EZINTO ZE-BIOMEDICAL
I-Gelatin, impahla yemvelo ye-biopolymer, iyisengezo sokudla esilungiselelwe i-hydrolysis emaphakathi yamathambo ezilwane, izikhumba, izintambo, izintambo nezikali.Akukho lutho oluqhathaniswa nalolu hlobo lwezinto eziphilayo ku-gelatin, ngenxa ye-biodegradability yayo, i-biocompatibility enhle, ijeli kanye nezindleko eziphansi.Ngakho-ke, i-gelatin isetshenziswe kabanzi njenge-excipient yendabuko yemithi ezintweni ze-biomedical.
IgaziSubstitutes
Ukumpontshelwa igazi kuyadingeka ezimweni eziningi, njengokuhlinzwa ingxenye noma ukopha okukhulu kakhulu.Kodwa-ke, ukushoda komthombo wegazi, ukumiswa kwegazi okuyinkimbinkimbi uma kuqhathaniswa, kanye nengozi yokunikezwa kwegazi le-allogeneic nakho kuphazamisa ukufika kwesikhathi, ukusebenza kahle nokuphepha kokwelashwa komtholampilo ngezinga elikhulu.Indlela yokufakwa esikhundleni se-plasma ingaxazulula lezi zinkinga, ngakho-ke inamandla amakhulu okusebenza komtholampilo kanye nesikhala sokuthuthukiswa kobuchwepheshe.Ngakho-ke, izinto ze-gelatin, ezifana ne-succinyl gelatin ne-polygelatin peptide, zisetshenziswa kabanzi njenge-plasma esikhundleni se-plasma emtholampilo.Izimela ze-gelatin plasma zizosetshenziswa ezimeni eziphuthumayo ezifana nokuncipha kwevolumu yegazi kanye nokushaqeka.Ukungena kwe-Colloid kungandisa umthamo wegazi futhi kuthuthukise i-microcirculation.Izithako zegazi zeGelatin zinezinzuzo eziningi, njengokuwohloka, okokufaka okukhulu, okungezona ubuthi, okungezona i-immunogenicity nokunye.
HemostaticMizinto zokwakha
Eminyakeni yamuva, umphakathi wezokwelapha uye wanaka kakhulu ukuthuthukiswa kwezinto ezintsha ze-hemostatic.Isiponji se-gelatin esimuncwayo sidonse ukunaka okukhulu ngoba sinezinzuzo zomphumela omuhle we-hemostatic, intengo ephansi kanye nokucutshungulwa okuqinile.Indlela ye-hemostatic ye-gelatin hemostatic sponge iwukukhiqiza ukwakheka kwe-reticular ngokuvimba imithambo yegazi, ukuze ihlanganise amaplatelet futhi ifake i-fibrinogen.Lokhu kuzuzisa kakhulu ekwakhekeni kwe-thrombosis, ukuze kuncishiswe isikhathi sokuhlangana futhi ekugcineni kumise ukopha.Ngokwendlela yayo yokuhlangana, isiponji se-gelatin hemostatic sinemisebenzi ebalulekile yokucindezelwa ngomshini nokumuncwa kwamanzi.Kuyo yonke inqubo ye-coagulation, isibonelo, ayidlali indima ebalulekile ekukhuthazeni ukukhiqizwa kwezinqubo ezibalulekile ze-hemostatic ezifana nokusebenza kwe-prothrombin.Isipontshi se-gelatin esimunca esivamile esisetshenziswa emtholampilo sinezinkinga eziningi, njengokusabela okukhulu kwezicubu zangaphandle, ukusebenza kahle okuphansi kwe-hemostatic kanye nokuwa kalula.Njengamanje, i-gelatin ivame ukuguqulwa noma ihlanganiswe nezinye izinto ukuze kukhiqizwe izinto ze-hemostatic ezisebenza kahle kakhulu.
OkunyeAizicelo
I-Gelatin ngokuyinhloko ivela ku-collagen ezicutshini zomzimba, ngakho-ke inezinto eziphilayo ezivelele kakhulu, ezifana nokuvumelana okuhle kwe-biocompatibility kanye ne-biodegradability, ngakho-ke iye yasetshenziswa kabanzi emkhakheni wezinto eziphilayo.I-Gelatin ingasetshenziswa hhayi kuphela kulezi zici ezingenhla, kodwa futhi ekwelapheni izifo zesikhumba.Isibonelo, i-gelatin ene-hydrolyzed ingakwazi ukwelapha isikhumba esiphukile, ichthyosis kanye ne-dandruff.Ngaphezu kwalokho, i-gelatin nayo isetshenziswe kabanzi emithini yangaphakathi.Ku-Pharmacopoeia yaseShayina, kuchazwa ukuthi i-gelatin ye-macromolecular inemiphumela yokomisa okumanzi nokukhiqiza igazi, futhi inemiphumela ethile yokwelapha ezimpawu eziningi ezifana ne-anemia nokulahlekelwa kwegazi.I-gelatin ene-hydrolyzed nayo inomphumela osobala kakhulu ekwelapheni i-gastritis engapheli nezinye izimpawu.
Isikhathi sokuthumela: Aug-11-2021
