UKUSETSHENZISWA KWE-GELATIN EZINTWENI ZE-BIOMEDICAL
I-Gelatin, into yemvelo ye-biopolymer, iyisengezo sokudla esilungiselelwe ngokugeleza okulinganiselwe kwamathambo ezilwane, izikhumba, imisipha, imisipha kanye nezikali. Akukho lutho olufana nalolu hlobo lwezinto ze-biomedical ku-gelatin, ngenxa yokubola kwayo, ukuhambisana okuhle kwezinto ze-biomedical, ijeli kanye nezindleko eziphansi. Ngakho-ke, i-gelatin isetshenziswe kabanzi njengesithako sendabuko semithi ezintweni ze-biomedical.
IgaziSizithasiselo
Ukumpontshelwa igazi kuyadingeka ezimweni eziningi, njengokuhlinzwa okungaphelele noma ukuphuma kwegazi okukhulu kakhulu. Kodwa-ke, ukushoda komthombo wegazi, ukwakheka kwegazi okuyinkimbinkimbi, kanye nengozi yokutholakala kwegazi eli-allogeneic nakho kuphazamisa isikhathi, ukusebenza kahle kanye nokuphepha kokwelashwa kwezokwelapha ngezinga elikhulu. Indlela yokushintsha i-plasma ingaxazulula lezi zinkinga, ngakho-ke inamandla amakhulu okusetshenziswa kwezokwelapha kanye nendawo yokuthuthukisa ubuchwepheshe. Ngakho-ke, izinto ze-gelatin, njenge-succinyl gelatin kanye ne-polygelatin peptide, zisetshenziswa kabanzi njengezithathi ze-plasma emtholampilo. Izithathi ze-gelatin plasma zizosetshenziswa ezimweni eziphuthumayo njengokwehla kwevolumu yegazi kanye nokushaqeka. Ukungena kwe-Colloid kungandisa ivolumu yegazi futhi kuthuthukise i-microcirculation. Izithathi ze-gelatin blood substitute zinezinzuzo eziningi, njengokubola, ukufaka okukhulu, okungenabo ubuthi, ukungavikeleki komzimba njalo njalo.
HukuzwelaMi-aterials
Eminyakeni yamuva nje, umphakathi wezokwelapha ugxile kakhulu ekwakhiweni kwezinto ezintsha ze-hemostatic. Isiponji se-gelatin esimuncwayo sidonse ukunaka okukhulu ngoba sinezinzuzo zomphumela omuhle we-hemostatic, intengo ephansi kanye nokucutshungulwa okuqinile. Indlela ye-hemostatic yesiponji se-hemostatic se-gelatin iwukukhiqiza isakhiwo se-reticular ngokuvimba imithambo yegazi, ukuze kuhlanganiswe ama-platelet futhi kufakwe i-fibrinogen. Lokhu kuzuzisa kakhulu ekwakhekeni kwe-thrombosis, ukuze kuncishiswe isikhathi sokujiya futhi ekugcineni kumiswe ukopha. Ngokwendlela yaso yokujiya, isiponji se-hemostatic se-gelatin sinemisebenzi ebalulekile yokucindezela ngomshini kanye nokumuncwa kwamanzi. Kuyo yonke inqubo yokujiya, isibonelo, asidlali indima ebalulekile ekukhuthazeni ukukhiqizwa kwezinqubo ezibalulekile ze-hemostatic ezifana nokusebenza kwe-prothrombin. Isiponji se-gelatin esimuncwayo esivamile esisetshenziswa emtholampilo sinezinkinga eziningi, njengokusabela okukhulu kwemizimba yangaphandle yezicubu, ukusebenza kahle kwe-hemostatic okuphansi kanye nokuwa kalula. Njengamanje, i-gelatin ivame ukuguqulwa noma ihlanganiswe nezinye izinto ukuze ikhiqize izinto ze-hemostatic ezisebenza kahle kakhulu.
OkunyeAizicelo
I-Gelatin ikakhulukazi ivela ku-collagen ezicutshini zomzimba, ngakho-ke inezakhiwo ezinhle kakhulu zebhayoloji, njengokuhambisana okuhle kwezinto eziphilayo kanye nokubola kwazo, ngakho-ke isetshenziswe kabanzi emkhakheni wezokwelapha. I-Gelatin ingasetshenziswa hhayi kuphela ezicini ezingenhla, kodwa futhi nasekwelapheni izifo zesikhumba. Isibonelo, i-gelatin e-hydrolyzed ingalapha isikhumba esiqhekekile, i-ichthyosis kanye ne-dandruff. Ngaphezu kwalokho, i-gelatin nayo isetshenziswe kabanzi kwezokwelapha zangaphakathi. Ku-Chinese Pharmacopoeia, kuchazwa ukuthi i-gelatin yama-macromolecular inemiphumela yokumanzisa ukoma nokukhiqiza igazi, futhi inemiphumela ethile yokwelapha ezimpawini eziningi ezifana ne-anemia kanye nokulahlekelwa yigazi. I-gelatin e-hydrolyzed nayo inomphumela osobala kakhulu ekwelapheni i-gastritis engapheli nezinye izimpawu.
Isikhathi sokuthunyelwe: Agasti-11-2021
