Ngesizathu esihle,gelatiningenye yezinto ezisetshenziswa kakhulu kwezemithi kanye nezicelo zezokwelapha.Ibekezelelwa cishe emhlabeni wonke, inezici ezizuzisa kakhulu zokunwebeka nezici ezicacile, iyancibilika lapho izinga lokushisa lomzimba lishisa, futhi iyakwazi ukushibilika.I-Gelatin iyisithako esivumelana nezimo kakhulu esinezinzuzo ezihlukahlukene zemikhiqizo yezemithi njengamaphilisi namaphilisi, phakathi kokunye.
Womabili amagobolondo amaphilisi aqinile nathambile ngokuvamile enziwa nge-gelatin, evikela ngempumelelo okuqukethwe ekungcoleni okuphuma emoyeni, ukukhula kwamagciwane, ukukhanya, umoya-mpilo, ukungcola, nokunambitha kanye nephunga.
Amaphilisi Aqinile
Amaphesenti angama-75 emakethe ye-gelatin capsule enziwe ngamaphilisi aqinile.1 Aphinde abizwe ngokuthi ama-capsules aneziqephu ezimbili futhi akhiwe ngamagobolondo angamacylindrical amabili ahlanganiswe ndawonye ngekepisi elilingana kahle phezu komzimba.Kubantu, zingenziwa ngosayizi ukusuka ku-00 kuya ku-5, futhi zingashintsha noma zibe nombala.Kungenzeka futhi ukuphrinta.
Ama-powders, ama-granules, ama-pellets, namaphilisi amancane avame ukusetshenziswa njengezigcwalisi zamaphilisi aqinile.Ngokusebenzisa amasu adalwe ukuvala nokupakisha amaphilisi ngenkathi kugcizelelwa imithetho yokuphepha kwezidakamizwa, angabuye agcwaliswe ngoketshezi nokunamathisela.
Amaphilisi Athambile
Amaphilisi athambile, ngakolunye uhlangothi, azuza kuwoi-gelatin yemithiamandla okuncibilika emanzini ashisayo futhi aqine lapho kubanda.Banocezu olulodwa, igobolondo eliguquguqukayo elivalwe nge-hermetically.Angakwazi ukukhiqiza amagobolondo anezinhlobonhlobo zamafomu nemibala ngokusebenzisa uketshezi oluwuketshezi noma isigcwalisi esiqinile.
Yize noma ebala cishe amaphesenti angama-25 kuphela emakethe ye-gelatin capsule, amaphilisi athambile anezinzuzo ezahlukahlukene kumafomu amaningi ajwayelekile womthamo womlomo.Kubandakanya ukwanda kokugwinya, ukuvikelwa kwama-API, kanye nokuqedwa okusheshayo oketshezini lwesisu lwepheshana lesisu.Ngaphezu kwalokho, uma kuqhathaniswa namafomu omthamo ojwayelekile, ukumuncwa kwezinto ezingancibiliki kahle ezifakwe kumaphilisi athambile kungase kunyuswe.
Izibhebhe
I-Gelatin ingasetshenziswa njenge-coating noma i-binder yamaphilisi, inikeze inketho ethengekayo kuma-capsules.Alikho ithuba lokuxhumanisa namathebulethi, aphinde anikeze inketho yokukhetha ukuhlukaniswa komthamo.
Amathebulethi, ngakolunye uhlangothi, angasetshenziswa kuphela ngezinto ezisizayo eziqinile nama-API, futhi ukuncibilika kuhamba kancane, ukubunjwa kuyinselele enkulu, futhi kunokuvikelwa okuncane kwezingxenye ezisebenzayo emoyeni nasekukhanyeni.Ngaphezu kwalokho, ukugwinya kunzima kakhulu.
Ngesikhathi se-granulation, i-gelatin ingasebenza njengesibophezelo ukuze ibambe izimpushana ezifana nesitashi, okuphuma ku-cellulose, kanye ne-gum acacia ndawonye.Izembatho ze-gelatin nazo zingasiza ekubhekaneni nokunye ukushiyeka kwamaphilisi.Kubandakanya ukuthuthukisa ukugwinya, ukwehlisa ukunambitheka kanye nephunga, nokusiza ekuvikeleni ama-API kumoya-mpilo nokukhanya, phakathi kwezinye izinto.
Amadivayisi Ezokwelapha
IGelatin inezinzuzo ezimbalwa eziyenza ilungele uhla lwezicelo zokunakekelwa kwezempilo.Cishe ibekezelelwa emhlabeni wonke, ine-cytocompatibility enhle kakhulu kanye ne-immunogenicity encane.Ibuye ihlanzwe kakhulu ngaphandle kwengozi yokungcola futhi, ngaphezu kwemingcele ephathekayo ephathekayo, inikeza ukukhiqizwa okukhiqizwa kabusha kakhulu.
Ukusetshenziswa kwayo kuhlanganisa izipanji ze-hemostatic, ezingagcini nje ngokumisa ukuphuma kwegazi ngokuphumelelayo, kodwa futhi ziyakwazi ukumuncwa futhi zisheshise inqubo yokuphulukisa ngokukhuthaza ukufuduka kwamangqamuzana ezicubu ezintsha.Phakathi naleso sikhathi, ama-ostomy patches asebenzisa i-gelatin njengento yokunamathisela esikhumbeni.
Sicela uzizwe ukhululekile ukuxhumana nathi Gelken, uchwephesheumkhiqizi we-gelatin e-China, ukuze uthole imininingwane eyengeziwe nokucaciswa.
Isikhathi sokuthumela: Mar-09-2023
