UKUNGQONDO OKUTHATHU NGOKUPHAMBENE NE-COLLAGEN
Okokuqala, kuvame ukushiwo ukuthi "i-collagenakuyona umthombo omuhle kakhulu wamaprotheni wokudla kwezemidlalo."
Ngokuphathelene nokudla okuyisisekelo, i-collagen ngezinye izikhathi ihlukaniswa njengomthombo wamaprotheni ongaphelele ngezindlela zamanje zokuhlola ikhwalithi yamaprotheni ngenxa yokuqukethwe kwayo okuphansi kwama-amino acid abalulekile. Kodwa-ke, indima esebenzayo ye-collagen idlula indima eyisisekelo yokudla okunempilo yamaprotheni ngokufaka isandla kuma-amino acid abalulekile ukuze kuhlangatshezwane nezidingo zansuku zonke. Ngenxa yesakhiwo sayo esiyingqayizivele se-peptide, ama-bioactive collagen peptides (i-BCP) abopha kuma-receptor athile ebusweni beseli futhi akhuthaze ukukhiqizwa kwamaprotheni e-extracellular matrix. Umphumela wayo awuhlobene ne-essential amino acid spectrum noma i-protein quality score ye-collagen.
Okwesibili, abathengi badidekile mayelana nokuhlukaniswa kwama-peptide e-collagen.
Ukusatshalaliswa kwe-collagen emzimbeni kuyinkimbinkimbi. Kodwa kungakhathaliseki ukuthi zikuphi, ukuhlukaniswa kwezinhlobo ze-collagen (ezingu-28 sezitholakale kuze kube manje) akuthinti ukusebenza kwe-bioactivity yama-peptide abo e-collagen njengomthombo wokudla okunempilo. Isibonelo, ngokusho kwezilingo ezahlukahlukene zangaphambi kokwelashwa, i-collagen yohlobo I nohlobo II ikhombisa cishe ukulandelana okufanayo kwamaprotheni (cishe u-85%), futhi lapho i-collagen yohlobo I nohlobo II i-hydrolyzes ibe ama-peptide, umehluko wayo awunawo umthelela ekusebenzeni kwe-bioactivity noma ekukhuthazeni kwamaseli ama-peptide e-collagen.
Okwesithathu, ama-peptide e-collagen ebhayoloji awavikelekile ekugayweni kwe-enzyme emathunjini.
Uma kuqhathaniswa namanye amaprotheni, i-collagen inesakhiwo esiyingqayizivele se-amino acid chain esiza ukuthuthwa kwama-peptide asebenzayo odongeni lwamathumbu. Uma kuqhathaniswa nokwakheka kwe-α helical kwamanye amaprotheni, ama-peptide e-collagen ebhayoloji anesakhiwo eside, esincane futhi amelana kakhulu ne-hydrolysis yamathumbu. Lesi sici senza kube wusizo ekumuncweni okuhle nasekuzinzeni emathunjini.
Namuhla, ukusetshenziswa kudlula izidingo eziyisisekelo futhi kugxile kuma-amino acid abalulekile anemibandela kanye namakhemikhali okudla asebenzayo njengezindlela zokulawula i-metabolic ezingaletha izinzuzo zezempilo ezinhle kakhulu nezesikhathi eside emzimbeni futhi zihlangabezane nezidingo ezithile zomzimba ezifana nokulwa nokuguga kanye nokunciphisa ukulimala kwezemidlalo. Ngokuphathelene nokuqonda kwabathengi, i-collagen isibe ngomunye wemithombo eyinhloko yama-peptide asebenzayo.
Isikhathi sokuthunyelwe: Septhemba 15-2021
